Job Description

Regeneron’s Product Biochemistry in Tarrytown, NY is seeking a motivated and innovative Senior Scientist to drive late-stage development (Phase II through commercialization) of biologics. You will develop and deploy analytical methods and purification strategies, enrich and characterize product variants, and help onboard new technologies that deepen product understanding and improve processes across the pipeline. This role is for you if you are scientifically creative, hardworking, efficient, flexible, and able to perform key responsibilities in a fast-paced, team environment.

Key Responsibilities:

• Develop analytical methods and purification protocols to support extended characterization of therapeutic proteins and gene therapy vectors.
• Conduct biochemical/biophysical characterization to support development, regulatory submissions, and commercialization.
• Apply DOE, advanced statistics, and risk assessments to evaluate and optimize methods and processes.
• Author high-quality technical documents (protocols, reports, memos) and contribute to regulatory sections and publications. Ensure timely documentation of experiments following established SOPs and guidelines.
• Maintain instruments, troubleshoot issues, and improve lab/data workflows within your area of expertise. Adhere to procedures, guidance, and best practices to ensure lab safety.

• Proactively identify process improvement opportunities across Product Biochemistry and Regeneron and help drive implementation.

A Typical Day in the Role Might Look Like:

• Design and execute experiments to enrich, purify, and characterize size/charge variants, complexes, and high-concentration formulations.
• Integrate learnings from internal data and external literature to make science-based study design recommendations.
• Documents experiments, results and findings in electronic laboratory notebook; presents work at group and department meetings; contributes to drafting of protocols, method development reports, regulatory submission sections, and peer-reviewed articles for publication.
• Lead or participate in technology initiatives and continuous improvement projects; may also mentor and guide junior analysts in a matrix-based environment.
• Maintain instruments, troubleshoot instrumental/experimental problems, and order/maintain supplies.

This Role Might Be For You If:

• Possess strong lab skills in protein separation, purification, and tangential flow filtration (TFF). Possess skills in protein/product identification using mass spectrometry.
• Thrive in a fast-paced, team environment and can also work independently across multiple projects.
• Demonstrate initiative, calculated risk-taking, and a passion for innovation and continuous improvement.
• Communicate clearly, manage projects effectively, and solve complex problems with data-driven rigor.
• Mentor others and contribute to a safe, efficient, and inclusive lab environment.

This role requires a BS/MS/Ph.D. in Biochemistry/Biophysics, or related field plus 8-10 yrs+ (BS/MS) or 0-2 yrs+ of proven experience (Ph.D.). Technical proficiency in automated FPLC and/or HPLC (SEC, IEX, affinity), electrophoresis (capillary or microchip, SDS-PAGE, western blots), spectroscopy and light scattering is recommended. A fundamental understanding of protein structure/function, mass spectrometry, and immunology/immunogenicity preferred. Preference will be given to candidates who have experience working in the biopharmaceutical industry. Excellent oral and written communication skills and evidence of teamwork are required. This role is fully onsite.

The ideal candidate must have strong initiative to complete tasks, learn new technologies, and demonstrate a commitment to continuous learning. This role requires the ability to manage multiple priorities in a fast‑moving R&D environment, operate effectively both independently and within a collaborative team environment, and communicate clearly, transparently, and in a timely manner with key stakeholders.

Does this sound like you? Apply now to take your first step towards living the Regeneron Way! We have an inclusive culture that provides comprehensive benefits, which vary by location. In the U.S., benefits may include health and wellness programs (including medical, dental, vision, life, and disability insurance), fitness centers, 401(k) company match, family support benefits, equity awards, annual bonuses, paid time off, and paid leaves (e.g., military and parental leave) for eligible employees at all levels! For additional information about Regeneron benefits in the US, please visit For other countries’ specific benefits, please speak to your recruiter.
Please be advised that at Regeneron, we believe we are most successful and work best when we are together. For that reason, many of Regeneron’s roles are required to be performed on-site. Please speak with your recruiter and hiring manager for more information about Regeneron’s on-site policy and expectations for your role and your location.

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. The Company will also provide reasonable accommodation to the known disabilities or chronic illnesses of an otherwise qualified applicant for employment, unless the accommodation would impose undue hardship on the operation of the Company's business.

For roles in which the hired candidate will be working in the U.S., the salary ranges provided are shown in accordance with U.S. law and apply to U.S.-based positions. For roles which will be based in Japan and/or Canada, the salary ranges are shown in accordance with the applicable local law and currency. If you are outside the U.S, Japan or Canada, please speak with your recruiter about salaries and benefits in your location.

Please note that certain background checks will form part of the recruitment process. Background checks will be conducted in accordance with the law of the country where the position is based, including the type of background checks conducted. The purpose of carrying out such checks is for Regeneron to verify certain information regarding a candidate prior to the commencement of employment such as identity, right to work, educational qualifications etc.

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